کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535097 | 1559107 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X2/3 receptor function and exerts an analgesic effect in pain models
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
The P2X2/3 receptor has an important role in the nociceptive transmission. Minodronic acid is a third third-generation bisphosphonate and a potent inhibitor of bone resorption. We found that minodronic acid inhibited α,β-methylene ATP-induced cation uptake with the potency higher than that of suramin in the P2X2/3 receptor receptor-expressing cells. Other bisphosphonates did not show such activity. Subcutaneously administered (10–50 mg/kg) minodronic acid significantly inhibited the α,β-methylene ATP-, acetic acid- and formalin-induced nociceptive behaviors in mice. These unique effects of minodronic acid would be beneficial for the treatment of accelerated bone turnover diseases accompanied by bone pain, including bone metastases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 589, Issues 1–3, 28 July 2008, Pages 98–101
Journal: European Journal of Pharmacology - Volume 589, Issues 1–3, 28 July 2008, Pages 98–101
نویسندگان
Shuichiro Kakimoto, Yukinori Nagakura, Seiji Tamura, Tomonari Watabiki, Kumiko Shibasaki, Shohei Tanaka, Masamichi Mori, Masao Sasamata, Masamichi Okada,