کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535253 | 1559111 | 2008 | 4 صفحه PDF | دانلود رایگان |

Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dtsz mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic episodes. Previous examinations have shown changes in kynurenic acid levels and antidystonic effects of the kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfon-amide (Ro 61-8048) after systemic treatment in dtsz hamsters. In the present study, intrastriatal injections of Ro 61-8048 (60–80 μg/hemisphere) significantly reduced the severity of dystonia in dtsz hamsters, suggesting that kynurenine 3-hydroxylase inhibitors may be interesting candidates for managing dyskinesias which are related to striatal dysfunction.
Journal: European Journal of Pharmacology - Volume 586, Issues 1–3, 31 May 2008, Pages 156–159