کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535517 | 1559120 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of taurine as a biomarker of liver damage in paracetamol poisoning
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Taurine is one of the most abundant amino acids in the body. Plasma taurine levels of 217 paracetamol positive and 100 paracetamol negative poisoned patients (related to non-hepatotoxic agents) referred to the Toxicology lab in Cardiff Poisons unit and 90 healthy humans (age between 18 and 45) were measured by a high performance liquid chromatography method. The data were analysed using linear regression and two-tailed unpaired student t-test using Prism software package. We showed that the mean plasma taurine concentration in the paracetamol-poisoned patients (mean 26.4 ± 1.6 mg/l) was significantly different from the control groups (mean 5.6 ± 0.2 mg/l) (P < 0.0001) and the non-paracetamol group (mean 18.1 ± 1.1 mg/l) (P < 0.01). Taurine is produced by the liver in response to a toxic insult and subsequent leakage from damaged cells leads to increased concentrations in plasma and urine. Therefore a plasma or urinary taurine concentration could be a useful marker for paracetamol-induced hepatic damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 581, Issues 1â2, 26 February 2008, Pages 171-176
Journal: European Journal of Pharmacology - Volume 581, Issues 1â2, 26 February 2008, Pages 171-176
نویسندگان
Mohammadreza Ghandforoush-Sattari, Siminozar Mashayekhi,