کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535607 | 1559127 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological evidence that 5-HT1B/1D receptors mediate hypotension in anesthetized rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
5-Carboxamidotryptamine (5-CT; 0.003-310 μg/kg, i.v.) produced dose-dependent hypotensive responses which were blocked in a complex manner by the 5-HT7 receptor antagonist, (R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl) ethyl] pyrrolidine (SB-269970; 1 mg/kg, i.v.), in anesthetized vagosympathectomized rats. Interestingly, the 5-HT1B/1D receptor antagonist, N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2â²-methyl-4â²-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1-biphenyl]-4-carboxamide hydrochloride monohydrate GR-127935 (1 mg/kg, i.v.), also inhibited 5-CT-induced hypotension but the effect was clearly noncompetitive. Finally, the combination of GR-127935 + SB-269970 (1 mg/kg, i.v., each) produced a further decreased of 5-CT-induced responses as compared to the effect of individual treatments. These data suggest that, in addition to 5-HT7 receptors, 5-HT1B/1D receptors may also mediate hypotension in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 576, Issues 1â3, 8 December 2007, Pages 132-135
Journal: European Journal of Pharmacology - Volume 576, Issues 1â3, 8 December 2007, Pages 132-135
نویسندگان
José A. Terrón, Carolina Sánchez-Maldonado, Esther MartÃnez-GarcÃa,