کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535892 | 1559131 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes](/preview/png/2535892.png)
UTP causes IL-6 production in HaCaT keratinocytes, which is partially inhibited by PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor, suggesting that a pathway other than the extracellular signal-regulated kinase (ERK) pathway is involved in the production. In the present study, we examined the involvement of calcineurin in the UTP-induced interleukin (IL)-6 production in HaCaT keratinocytes. FK506 and cyclosporine A, calcineurin inhibitors, partially inhibited UTP-induced IL-6 mRNA expression and protein production. In addition, combined application of FK506 and PD98059 synergistically inhibited the UTP-induced IL-6 production. These results suggest that ERK and calcineurin are cooperatively involved in UTP-induced IL-6 production.
Journal: European Journal of Pharmacology - Volume 573, Issues 1–3, 14 November 2007, Pages 249–252