کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2535903 1559135 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
چکیده انگلیسی

Myocardial ischemia induces 5-lipoxygenase (LOX) translocation and leukotriene production in the heart. Leukotrienes increase inflammatory responses and could thereby aggravate ischemic injury. However, the role of lipoxygenase and leukotrienes in cardiac ischemia/reperfusion damage has not been well defined. Therefore, we tested the effect of ischemia reperfusion in mice with targeted deletion of 5-lipoxygenase, the enzyme converting arachidonic acid in leukotrienes. 5-LOX deficient (KO) and wild-type (WT) mice underwent 30 min of coronary artery ligation and 24 h of reperfusion in vivo. In mice with equivalent area at risk, infarct size was not significantly different between WT and KO mice (infarct/area at risk 61.7 ± 3.9 vs. 55.8 ± 6.6%, WT vs. KO, P = n.s.). However, neutrophil infiltration as well as tumor necrosis factor expression were increased in 5-lipoxygenase deficient mice. In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 571, Issue 1, 24 September 2007, Pages 51–54
نویسندگان
, , , , , , ,