کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535988 | 1559139 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Roles of axonal voltage-dependent ion channels in damaged peripheral nerves Roles of axonal voltage-dependent ion channels in damaged peripheral nerves](/preview/png/2535988.png)
Ion channels are fundamental to the correct functioning of nerves. A high density of Nav channels at nodes of Ranvier is crucial for generating sufficient local current to initiate a self-regenerating action potential. Kv7 (KCNQ) channels are also functional components of nodes of Ranvier and contribute to the repolarization of the action potential. Paranodes underlying the paranodal loops have no channels whereas Kv1.1 and Kv1.2 channels cluster at juxtaparanodes. The disruption of the normal balance of different channels causes the inappropriate nerve activity that underlies a variety of nervous system diseases. Axonal voltage-dependent channels, nodal Nav and juxtaparanodal Kv channels disperse after the nerve injury and reorganize with regeneration.
Journal: European Journal of Pharmacology - Volume 568, Issues 1–3, 30 July 2007, Pages 25–30