کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2536005 1559139 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain
چکیده انگلیسی

The antinociceptive effects of WIN55,212-2, a synthetic cannabinoid, were evaluated in the model of partial sciatic nerve ligation after daily subcutaneous administration of 0.1 mg/kg a week before and two weeks after surgery. Mechanical allodynia and thermal hyperalgesia were evaluated in 46 rats allocated to receive: (1) Vehicle (before surgery) − Vehicle (after surgery); (2) Vehicle − WIN55,212-2; (3) WIN55,212-2 − Vehicle; (4) WIN55,212-2 − WIN55,212-2; (5) AM251 + vehicle; (6) AM251 + WIN55,212-2; (7) AM630 + vehicle; (8) AM630 + WIN55,212-2; (9) Sham receiving vehicle; and (10) Sham receiving WIN55,212-2. The decreased in mechanical allodynia and thermal hyperalgesia by WIN55,212-2 was significantly greater when it was administered during one week before surgery. In conclusion, pre-emptive use of cannabinoids produced greater antinociceptive effects in a model of neuropathic pain and this effect is mediated by cannabinoid CB1 and CB2 receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 568, Issues 1–3, 30 July 2007, Pages 173–176
نویسندگان
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