کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2536651 | 1559165 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Baclofen and potential therapeutic use: Studies of neuronal survival
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Up to now, baclofen (a GABAB receptor agonist) has been used for the treatment of severe spasticity unresponsive to oral antispasmodics. Although in humans it is usually administered at 2Â mg/ml, the dosage to be used in the treatment of other diseases is unknown. For this reason, it is important to determine the safe maximum dosage and toxicity at the clinically used concentration. Primary cortical neurons represent a useful model to test the safety of baclofen. We performed a colorimetric assay (MTT test) as well as electron microscopy investigations, to determine neuronal survival after the treatment with baclofen at a concentration of 2 and 4Â mg/ml. Our results demonstrated that, in our experimental model, neither concentration affected neuronal survival. Considering the above results, we can conclude that at the used concentrations, this drug is safe and its clinical use should be encouraged.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 550, Issues 1â3, 21 November 2006, Pages 33-38
Journal: European Journal of Pharmacology - Volume 550, Issues 1â3, 21 November 2006, Pages 33-38
نویسندگان
Alessandro Dario, Rossana Pisani, Simone Sangiorgi, Andrea Soragna, Marcella Reguzzoni, Marina Protasoni, Federico Pessina, Riccardo Fesce, Antonio Peres, Giustino Tomei,