کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2536653 1559165 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antinociceptive action of (±)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Antinociceptive action of (±)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid in mice
چکیده انگلیسی
The opioid receptor antagonist naloxone totally reverted tetrahydropyran derivative effects on both models. Morphine as well as tetrahydropyran derivative induced tolerance and sedation in mice. However, tetrahydropyran derivative-induced tolerance had its onset retarded and the sedative activity was lower when compared to that induced by morphine. These results indicate that this new substance develops an antinociceptive activity and may be used in the future as a substitute for traditional opioids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 550, Issues 1–3, 21 November 2006, Pages 47-53
نویسندگان
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