کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2536761 1559164 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevation of systolic blood pressure in an animal model of olanzapine induced weight gain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Elevation of systolic blood pressure in an animal model of olanzapine induced weight gain
چکیده انگلیسی

In the present study, we examined the effect of olanzapine on weight gain, systolic blood pressure and metabolic changes in rats. Female Sprague Dawley rats were treated with either vehicle or olanzapine (1 and 2 mg/kg i.p, twice daily) for 20 days. Body weight, food and water intake, systolic blood pressure, plasma glucose, insulin and lipid were measured. Olanzapine (1 and 2 mg/kg) significantly increased the body weight and systolic blood pressure. Whereas, food intake and plasma insulin and insulin resistance index, were elevated only at 1 mg/kg. In conclusion, olanzapine induced weight gain in rats is associated with elevation of systolic blood pressure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 551, Issues 1–3, 3 December 2006, Pages 112–115
نویسندگان
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