کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2536928 | 1559171 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Distinct roles of diverse nuclear factor-κB complexes in neuropathological mechanisms Distinct roles of diverse nuclear factor-κB complexes in neuropathological mechanisms](/preview/png/2536928.png)
The nuclear transcription factors κB (NF-κB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-κB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-κB in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-κB in brain dysfunctions arises from the identification of diverse NF-κB complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-κB complexes for the treatment of neurodegenerative disorders and memory dysfunctions.
Journal: European Journal of Pharmacology - Volume 545, Issue 1, 1 September 2006, Pages 22–28