کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537162 1559183 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a novel regulatory mechanism for norepinephrine transporter activity by the IP3 receptor
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Identification of a novel regulatory mechanism for norepinephrine transporter activity by the IP3 receptor
چکیده انگلیسی

The norepinephrine transporter (NET) plays a crucial role in noradrenergic neurotransmission and is a target of many antidepressants and psychostimulants. Intracellular Ca2+ is reportedly involved in regulating NET activity, but the detailed mechanism is not clear. We employed a norepinephrine uptake assay using SH-SY5Y cells and found that the IP3 receptor inhibitors, 2-aminoethoxydiphenyl borate and xestospongin C, reduced the NET Vmax. These reductions were accompanied by the decreased cell surface expression of NET. Our findings suggest that intracellular Ca2+ mobilized by IP3 receptor is required for the maintenance of NET activity. This adds another pathway involving Ca2+ for the regulation of NET to other known mechanisms providing intracellular Ca2+.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 536, Issues 1–2, 24 April 2006, Pages 62–68
نویسندگان
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