کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537325 1559179 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum
چکیده انگلیسی

Bradykinin is well known to have a biphasic action to contract and relax gastrointestinal tissue. However, no studies have investigated the potential action of bradykinin to affect the peristaltic reflex. In the present study, serosally applied bradykinin (1–1000 nM) and the bradykinin B2 receptor agonist, kallidin (1–1000 nM), had inhibitory actions and increased the pressure threshold for peristalsis (maximum changes seen at 1000 nM were ∼60 Pa), as did morphine (IC50 = 22.3 ± 4.8 nM; maximum increase in the pressure threshold was ∼130 Pa). Conversely, the B1 kinin receptor agonist, [des-Arg9]-bradykinin (1–1000 nM), had no effect (P > 0.05). Two potent B2 receptor antagonists, FR173657 (1 and 100 nM) and icatibant (10 nM), significantly antagonized the inhibitory action of serosally applied bradykinin on peristalsis (P < 0.01), whilst the B1 receptor antagonist, Lys-[des-Arg9, Leu8]-bradykinin (100 nM) was inactive (P > 0.05). In comparison, 5-hydroxytryptamine (1–1000 nM) facilitated peristalsis (EC50 = 37.7 ± 23.0 nM; maximum reduction of the pressure threshold for peristalsis was ∼76 Pa), as did FR173657 at 100 nM (reducing the pressure threshold for peristalsis by ∼15 Pa; P < 0.05) but icatibant at 10 nM was inactive (P > 0.05). The results indicate that bradykinin B2 receptors mediate an inhibition of peristalsis in the guinea pig isolated ileum.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 539, Issues 1–2, 6 June 2006, Pages 108–115
نویسندگان
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