کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537433 1559190 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold–Jarisch reflex via activation of stereoselective recognition sites
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold–Jarisch reflex via activation of stereoselective recognition sites
چکیده انگلیسی

We report here that l-S-nitrosocysteine elicits rapid dose-dependent reductions in mean arterial blood pressure, heart rate, cardiac output and renal sympathetic nerve activity in conscious rats whereas d-S-nitrosocysteine elicits minor responses. The reductions in mean arterial blood pressure, heart rate and cardiac output elicited by l- and d-S-nitrosocysteine were markedly diminished after blockade of cardiac muscarinic cholinergic receptors whereas the reductions in renal sympathetic nerve activity were not affected. The Bezold–Jarisch reflex-like pattern of responses elicited by the stereoisomers, suggests that (i) l- and l-S-nitrosocysteine may activate stereoselective recognition sites on vagal cardiopulmonary afferents, which elicit hemodynamic responses via increases in cardiovagal efferent nerve activity and decreases in sympathetic nerve activity, and (ii) l-S-nitrosocysteine is a more potent agonist of these recognition sites than is d-S-nitrosocysteine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 531, Issues 1–3, 15 February 2006, Pages 254–258
نویسندگان
, , ,