کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2537433 | 1559190 | 2006 | 5 صفحه PDF | دانلود رایگان |
We report here that l-S-nitrosocysteine elicits rapid dose-dependent reductions in mean arterial blood pressure, heart rate, cardiac output and renal sympathetic nerve activity in conscious rats whereas d-S-nitrosocysteine elicits minor responses. The reductions in mean arterial blood pressure, heart rate and cardiac output elicited by l- and d-S-nitrosocysteine were markedly diminished after blockade of cardiac muscarinic cholinergic receptors whereas the reductions in renal sympathetic nerve activity were not affected. The Bezold–Jarisch reflex-like pattern of responses elicited by the stereoisomers, suggests that (i) l- and l-S-nitrosocysteine may activate stereoselective recognition sites on vagal cardiopulmonary afferents, which elicit hemodynamic responses via increases in cardiovagal efferent nerve activity and decreases in sympathetic nerve activity, and (ii) l-S-nitrosocysteine is a more potent agonist of these recognition sites than is d-S-nitrosocysteine.
Journal: European Journal of Pharmacology - Volume 531, Issues 1–3, 15 February 2006, Pages 254–258