کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2537451 | 1559191 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relaxation and cyclic GMP levels in response to sildenafil in human pulmonary arteries from donors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
We measured cyclic GMP formation and relaxation response to sildenafil given either alone or in combination with sodium nitroprusside (SNP) in pulmonary arteries obtained from 13 multi-organ donors. Sildenafil (10− 9–10− 4 M) caused concentration-dependent relaxations and amplified the relaxation induced by SNP. Relaxation was unaffected by endothelium removal or by pre-treatment with the inhibitor of nitric oxide synthase L-NMMA (10− 4 M). SNP (10− 7 M) caused elevation of cyclic GMP levels that was potentiated by sildenafil (10− 6 M). Thus, the enhancement of SNP-induced relaxation by sildenafil is mainly due to an increase in cyclic GMP accumulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 530, Issue 3, 20 January 2006, Pages 259–262
Journal: European Journal of Pharmacology - Volume 530, Issue 3, 20 January 2006, Pages 259–262
نویسندگان
Maria D. Mauricio, Gloria Segarra, Pascual Medina, Martin Aldasoro, Juan B. Martínez-León, José M. Vila,