کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537451 1559191 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relaxation and cyclic GMP levels in response to sildenafil in human pulmonary arteries from donors
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Relaxation and cyclic GMP levels in response to sildenafil in human pulmonary arteries from donors
چکیده انگلیسی

We measured cyclic GMP formation and relaxation response to sildenafil given either alone or in combination with sodium nitroprusside (SNP) in pulmonary arteries obtained from 13 multi-organ donors. Sildenafil (10− 9–10− 4 M) caused concentration-dependent relaxations and amplified the relaxation induced by SNP. Relaxation was unaffected by endothelium removal or by pre-treatment with the inhibitor of nitric oxide synthase L-NMMA (10− 4 M). SNP (10− 7 M) caused elevation of cyclic GMP levels that was potentiated by sildenafil (10− 6 M). Thus, the enhancement of SNP-induced relaxation by sildenafil is mainly due to an increase in cyclic GMP accumulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 530, Issue 3, 20 January 2006, Pages 259–262
نویسندگان
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