کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537454 1559191 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
μ-Opioid influence on transmesothelial resistance of isolated sheep pleura and parietal pericardium
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
μ-Opioid influence on transmesothelial resistance of isolated sheep pleura and parietal pericardium
چکیده انگلیسی

The effect of morphine (μ-opioid receptor agonist) on the transmesothelial resistance (RTM) of sheep's pleura and parietal pericardium was studied using the Ussing chamber technique. Basal transmesothelial resistance of parietal pleura was found to be 19.57 ± 0.32 Ω cm2 and of visceral pleura was found to be 19.41 ± 0.31 Ω cm2, whereas that of parietal pericardium was found to be 22.83 ± 0.4 Ω cm2. Immediately after the addition of morphine (10− 9 M) both apically and basolaterally on the parietal pleura and parietal pericardium, these values were significantly increased (P < 0.05). On the contrary, addition of morphine (10− 9 M) resulted in a rapid increase, only when placed basolaterally on the visceral pleura (P < 0.05). In conclusion, our findings suggest that morphine, probably through μ-opioid stimulation, increases in vitro the transmesothelial resistance of the parietal pleura, of the visceral pleura when added basolaterally and of the parietal pericardium.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 530, Issue 3, 20 January 2006, Pages 276–280
نویسندگان
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