کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537551 1559192 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hemodynamic effects of bupropion in anesthetized dogs
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Hemodynamic effects of bupropion in anesthetized dogs
چکیده انگلیسی

Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/kg, i.v.) or in cumulative doses of 0.01, 0.1, 1, 3 and 10 mg/kg showed, in both studies, a significant increase of mean pulmonary arterial pressure and pulmonary vascular resistance index. These results show that bupropion can elevate the pulmonary pressure. Further investigations should be done to test this effect in smokers with chronic obstructive pulmonary disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 530, Issues 1–2, 13 January 2006, Pages 124–127
نویسندگان
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