کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538045 1559632 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C21 steroidal glycosides from the roots of Cynanchum paniculatum
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
C21 steroidal glycosides from the roots of Cynanchum paniculatum
چکیده انگلیسی

As a part of our continuing research for bioactive constituents from Cynanchum plants, four new C21 steroidal glycosides, cynapanoside D-G (1–4), together with six known compounds (5–10) were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. Compound 8 exhibited potent inhibitory activities against HL-60, HT-29, PC-3 and MCF-7 cell lines with IC50 values of 8.3, 7.5, 34.3 and 19.4 μM, respectively and compounds 1–4 and 9 displayed moderate cytotoxicity against the four cell lines. The in vitro antioxidant activities of compounds 1–4, 8 and 9 were assayed by DPPH radical scavenging activity. Antibacterial and antifungal activities of compounds 1–4, 8 and 9 were also tested.

As our current interest in the biologically active and structurally unique C21 steroidal glycosides, four new C21 steroidal glycosides, cynapanoside D-G (1–4) were identified from the roots of Cynanchum paniculatum. These compounds were evaluated for their cytotoxic, antioxidant and antimicrobial activities.Figure optionsDownload high-quality image (208 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 113, September 2016, Pages 51–57
نویسندگان
, , , , , , , , , ,