کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538045 | 1559632 | 2016 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: C21 steroidal glycosides from the roots of Cynanchum paniculatum C21 steroidal glycosides from the roots of Cynanchum paniculatum](/preview/png/2538045.png)
As a part of our continuing research for bioactive constituents from Cynanchum plants, four new C21 steroidal glycosides, cynapanoside D-G (1–4), together with six known compounds (5–10) were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. Compound 8 exhibited potent inhibitory activities against HL-60, HT-29, PC-3 and MCF-7 cell lines with IC50 values of 8.3, 7.5, 34.3 and 19.4 μM, respectively and compounds 1–4 and 9 displayed moderate cytotoxicity against the four cell lines. The in vitro antioxidant activities of compounds 1–4, 8 and 9 were assayed by DPPH radical scavenging activity. Antibacterial and antifungal activities of compounds 1–4, 8 and 9 were also tested.
As our current interest in the biologically active and structurally unique C21 steroidal glycosides, four new C21 steroidal glycosides, cynapanoside D-G (1–4) were identified from the roots of Cynanchum paniculatum. These compounds were evaluated for their cytotoxic, antioxidant and antimicrobial activities.Figure optionsDownload high-quality image (208 K)Download as PowerPoint slide
Journal: Fitoterapia - Volume 113, September 2016, Pages 51–57