Colletotrilactam A–D, novel lactams from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Four novel lactams, colletotrilactam A–D (1–4), along with six known compounds (5–10) were isolated from the culture broth of Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla. The structures of these compounds were elucidated by comprehensive NMR spectroscopy. Isolates were tested for monoamine oxidase (MAO) inhibitory activity and compound 9 showed potent MAO inhibitory activity with IC50 value of 8.93 ± 0.34 μg/mL, when the IC50 value of iproniazid as a standard was 1.80 ± 0.5 μg/mL.

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