کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538118 1559634 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B
چکیده انگلیسی

Nine new sesquiterpenoids, clitocybulol derivatives, clitocybulols G–O (1–9) and three known sesquiterpenoids, clitocybulols C–E (10 − 12), were isolated from the solid culture of the edible fungus Pleurotus cystidiosus. The structures of compounds 1–12 were determined by spectroscopic methods. The absolute configurations of compounds 1–9 were assigned via the circular dichroism (CD) data analysis. Compounds 1, 6 and 10 showed moderate inhibitory activity against protein tyrosine phosphatase-1B (PTP1B) with IC50 values of 49.5, 38.1 and 36.0 μM, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 111, June 2016, Pages 29–35
نویسندگان
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