کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538130 1559634 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron
چکیده انگلیسی

Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 111, June 2016, Pages 124–129
نویسندگان
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