Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood

Nine new sesquiterpenes (1–9), together with seventeen known ones (10–26), were isolated from Chinese eaglewood. Their structures were established by extensive spectroscopic analysis, and the absolute configuration of 6 was determined by the modified Mosher's method. Compounds 7, 10, 14, 15, and 21 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values in the range 7.1–53.8 μM.

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