Antiviral sesquiterpenes from leaves of Nicotiana tabacum

Three unreported sesquiterpenes possessing two new skeletons, tabasesquiterpenes A–C (1–3), together with three known sesquiterpenes (3–6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1–6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 2 exhibited high anti-TMV activity with inhibition rate of 35.2%, which were higher than that of positive control (ningnanmycin). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 20.5–28.6%.

Three unreported sesquiterpenes possessing two new skeletons, tabasesquiterpenes A–C (1–3), together with three known sesquiterpenes (4–6) were isolated from the leaves of Nicotiana tabacum. Compound 2 exhibited high anti-TMV activity with inhibition rate of 35.2%, which were higher than that of positive control (ningnanmycin).Figure optionsDownload high-quality image (94 K)Download as PowerPoint slide