کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538236 1559637 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase
ترجمه فارسی عنوان
مهار بروموفنولهای جلبک و فنول های مرتبط با آن در برابر گلوکز 6-فسفات دهیدروژناز
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L. mesenteroides G6PD.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 108, January 2016, Pages 20–25
نویسندگان
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