کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538241 1559637 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora
چکیده انگلیسی

ABSTRACTThe methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4′-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4–16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 108, January 2016, Pages 55–61
نویسندگان
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