کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538243 1559637 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RXRα transcriptional inhibitors from the stems of Calophyllum membranaceum
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
RXRα transcriptional inhibitors from the stems of Calophyllum membranaceum
چکیده انگلیسی

Bioassay-guided fractionation of the 60% ethanol extract of the stems of Calophyllum membranaceum using the RXRα transcription activation assay led to the isolation of two new chromanones, calopolyanic acid methyl ester (1) and isopinetoric acid methyl ester (2), two new xanthones, calophylixanthones A–B (3–4), and one new C-glycoside, calophymembranside C (5), along with 13 known compounds. Their structures were elucidated on the basis of extensive spectroscopic data. Compounds 5, 11 and 18 showed transcriptional inhibitory activity of RXRα with 50% inhibitory concentration (IC50) values of 29.95 ± 1.08, 31.06 ± 9.02, and 25.88 ± 1.62 μM, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 108, January 2016, Pages 66–72
نویسندگان
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