Seven new drimane-type sesquiterpenoids from cultures of fungus Laetiporus sulphureus

Seven new drimane-type sesquiterpenoids, sulphureuines B–H (1–7), together with four known compounds (8–11), were obtained from cultures of mushroom Laetiporus sulphureus. All of these compounds were tested for their cytotoxicities against five human cancer cell lines (HL-60, SMMC-721, A-549, MCF-7, SW-480), compound 10 showed potent cytotoxic activity against HL-60, SMMC-721, A-549, SW-480, with IC50 values of 37.5, 14.8, 15.6, and 36.1 μM, respectively.

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