کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538291 | 1559643 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitrogen-containing bibenzyls from Pleione bulbocodioides: Absolute configurations and biological activities
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nitrogen-containing bibenzyls from Pleione bulbocodioides: Absolute configurations and biological activities Nitrogen-containing bibenzyls from Pleione bulbocodioides: Absolute configurations and biological activities](/preview/png/2538291.png)
چکیده انگلیسی
Four new pyrrolidone substituted bibenzyls, dusuanlansins A–D (1–4) were isolated from the pseudo bulbs of Pleione bulbocodioides, along with 19 known compounds (5–23). Compounds 1–4 are two pairs of epimers of pyrrolidone substituted bibenzyls, which were separated successfully by a Chiralcel OD-RH C18 column. Their absolute configurations were elucidated by calculated ECD. Biological investigations showed that compounds 5 and 7 exhibited potent anti-inflammatory activities on LPS-stimulated NO production in BV-2 microglial cells, with IC50 values of 2.46 and 3.14 μM, respectively.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 102, April 2015, Pages 120–126
Journal: Fitoterapia - Volume 102, April 2015, Pages 120–126
نویسندگان
Yuan Li, Fan Zhang, Ze-Hong Wu, Ke-Wu Zeng, Chen Zhang, Hong-Wei Jin, Ming-Bo Zhao, Yong Jiang, Jun Li, Peng-Fei Tu,