کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538292 1559643 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of gentiopicroside on experimental acute pancreatitis induced by retrograde injection of sodium taurocholate into the biliopancreatic duct in rats
ترجمه فارسی عنوان
اثر ژنتیوپیکروزید بر پانکراتیت حاد ناشی از تزریق رتروگراد تزریق تائوروکلول سدیم به داخل مجرای بایلیوپروزیس در موش صحرایی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Gentiopicroside (otherwise known as Gentiopicrin), one of the main active ingredients from the traditional Chinese herb medicine Gentiana manshurica Kitag, presents the effect of attenuating acute pancreatitis in rats. The experimental acute pancreatitis was made by retrograde injection of sodium taurocholate into the biliopancreatic duct in rats. Gentiopicroside was given orally and it markedly reduced the pancreatitis-evoked increase of serum amylase and lipase activity, decreased the pancreas mass/body mass index, tissue water content, TNF-α and IL-1β concentrations, and attenuated the histopathological changes and NF-κB p65 protein expression in pancreatic tissue. The results indicate that the function of gentiopicroside on acute pancreatitis may be related to inhibiting the release of inflammatory mediators and NF-κB p65 protein expression.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 102, April 2015, Pages 127–133
نویسندگان
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