کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538343 1559642 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
چکیده انگلیسی

Nine new minor dehydrogenated and cleavaged dammarane-type triterpenoid saponins, namely notoginsenosides ST6-ST14 (1–9) were isolated from the steamed roots of Panax notoginseng, together with 14 known ones. Among them, 5–7 and 21–22 were protopanaxadiol type and the left 18 compounds, including 1–4, 8–20, and 23 were protopanaxatriol type saponins. Their structures were identified by extensive analysis of MS, 1D and 2D NMR spectra, and acidic hydrolysis. Resulted from the side chain cleavage, the new saponins 1 and 2 featured in a ketone group at C-25, and 3–5 had an aldehyde unit at C-23. The known saponins 12, 16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μM, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 μM.

Nine new minor dammarane-type saponins were isolated from the steamed roots of Panax notoginseng. The dienone or enone on the side chain of the saponins were the rare features in tetracyclic triterpenoids.Figure optionsDownload high-quality image (340 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 103, June 2015, Pages 97–105
نویسندگان
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