کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538356 1559642 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd
چکیده انگلیسی

Ten flavonoid glycosides, apetalumosides A (1), B1–B7 (2–8), and C (9), quercetin 3-O-(2,6-di-O-β-d-glucopyranosyl)-β-d-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Willd. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1–9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1–3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure–activity relationship study revealed that 7-hydroxyl group is an essential moiety.

Flavonoid glycosides obtained from the seeds of L. apetalum.Figure optionsDownload high-quality image (299 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 103, June 2015, Pages 197–205
نویسندگان
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