کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538383 1559640 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation, chemotaxonomic significance and cytotoxic effects of quassinoids from Brucea javanica
ترجمه فارسی عنوان
جداسازی، اهمیت شیمی درمانی و اثرات سیتوتوکسیک کازئینوئید از بروسا جاوینیکا
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

A new quassinoid, bruceene A (1) along with seventeen known quassinoids (2–18) was isolated from the fruits of Brucea javanica. The structure of 1 was elucidated by extensive spectroscopic methods, and was further confirmed by single-crystal X-ray diffraction analysis. Isolation of similar quassinoids 1–3 as those in genus Ailanthus from genus Brucea, indicated the close chemotaxonomic relationship between these two genera, which further supported the phylogenetic study by DNA analysis. Compounds 5, 7, 10 and 12 with a 3-hydroxy-3-en-2-one moiety showed potent inhibitory activities against the MCF-7 and MDA-MB-231 cells with IC50 values in the ranges 0.063–0.182 μM and 0.081–0.238 μM, respectively; while glycosidation at 3-OH significantly decreased the cytotoxicity. It was also found that the most potent compound 7 induced apoptosis in MCF-7 cells via the intrinsic mitochondrial apoptotic pathway.

A new quassinoid, bruceene A (1) along with seventeen known quassinoids (2–17) was isolated from the fruits of Brucea javanica.Figure optionsDownload high-quality image (119 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 105, September 2015, Pages 66–72
نویسندگان
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