Stachybisbins A and B, the first cases of seco-bisabosquals from Stachybotrys bisbyi

Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, together with three biogenetically related metabolites (3–5), were isolated from a wetland fungal strain of Stachybotrys bisbyi. The structures of the new compounds were determined by spectroscopic analyses, modified Mosher's method, and quantum chemical CD method. The cytotoxic activities of all compounds were tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.

Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, were isolated from a wetland fungal strain of Stachybotrys bisbyi. Their structures were determined by spectroscopic analyses, modified Mosher’s method, and quantum chemical CD method.Figure optionsDownload high-quality image (150 K)Download as PowerPoint slide