کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538403 1559640 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunosuppressive C21 steroidal glycosides from the root of Cynanchum atratum
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Immunosuppressive C21 steroidal glycosides from the root of Cynanchum atratum
چکیده انگلیسی

Six new C21 steroidal glycosides (1–6) and one dideoxysaccharide (7), named atratcynosides A–F and atratcynose A, were isolated from the 80% ethanol extract of the root of Cynanchum atratum, together with three known compounds (8–10). The structures of the new compounds were determined on the basis of extensive spectral analyses and qualitative chemical methods. All compounds were subjected to detect the immunosuppressive activities by an in vitro model of concanavalin A-induced proliferation of T-lymphocytes from mice. Compounds 1–3 showed significant immunosuppressive activities in dose-dependent manners with the IC50 values from 3.3 to 7.0 μM. Moreover, the structure–activity relationship of the steroidal glycosides on the immunosuppression was analyzed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 105, September 2015, Pages 194–201
نویسندگان
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