کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538408 1559640 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of substituted stilbenes on platelet function
ترجمه فارسی عنوان
اثر استیلبن های جایگزین بر عملکرد پلاکت
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Stilbenes, including resveratrol, are polyphenols provided with protective actions on the cardiovascular system. Some natural derivatives of resveratrol, like pterostilbene, have a better bioavailability than the parent compound. The aim of the present study was to prepare different substituted stilbenes (dimethylallyloxy-stilbene, dimethylallyloxy-pterostilbene) and compare them with resveratrol, p-hydroxy-stilbene and pterostilbene for their biologic activities on platelet aggregation, platelet radical oxygen species (ROS) production, and platelet nitric oxide (NO) synthesis. The results show that the increase of stilbene derivative lipophilicity enhances their biologic activities.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 105, September 2015, Pages 228–233
نویسندگان
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