Involvenflavones A–F, six new flavonoids with 3′-aryl substituent from Selaginella involven

Six new flavonoids, involvenflavones A–F (1–6), were isolated from Selaginella involven. Their structures were elucidated based on UV, IR, 1D and 2D NMR as well as HR-ESI-MS techniques. All compounds belong to apigenin derivatives with 3′-aryl substituent. This is the first report of the apigenin derivatives with 3′-aryl substituent from nature resources. These compounds also exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro.

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