Penthorin A and B, two unusual 2,4′-epoxy-8,5′-neolignans from Penthorum chinese

Two new 2,4′-epoxy-8,5′-neolignans (1 and 2), together with five known 7,9′;7′,9-diepoxylignans (3 − 7), were isolated from an ethyl acetate soluble portion of a hepatoprotective water decoction of Penthorum chinese. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. This is the second report of 2,4′-epoxy-8,5′-neolignans from plants. Compounds 2, 6, and 7 showed in vitro protective activities against acetaminophen-induced hepatocyte injury at 5 μM.

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