Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity

Scrodentosides A–E (1–5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 μM and 1.02 μM respectively.

► Phytochemicals of Scrophularia dentata were investigated for the first time.
► Five acylated C9-iridoid glycosides were identified to be new compounds.
► Compound 11 showed significant inhibitory effect against NF-κB activation.Figure optionsDownload high-quality image (402 K)Download as PowerPoint slide