کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538585 | 1559653 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A new glucomannan from Bletilla striata: Structural and anti-fibrosis effects A new glucomannan from Bletilla striata: Structural and anti-fibrosis effects](/preview/png/2538585.png)
A novel water-soluble polysaccharide, designated Bletilla striata polysaccharide b (BSPb), was isolated from a traditional Chinese medicinal herb, Bletilla striata. The crude polysaccharide was obtained by hot water extraction and purified by ion-exchange chromatography. The molecular weight was 260 kDa as determined by HPGPC (high performance gel permeation chromatography). Monosaccharide analysis showed that BSPb contained glucose and mannose with a molar ratio of 3:1. Methylation and spectroscopic analyses with 1D and 2D NMR spectroscopy showed that the backbone of BSPb is mainly composed of (1 → 2)-linked α-d-mannopyranose and (1 → 4)-linked β-d-glucopyranose residues. In this study, BSPb plays an important role in protection against the renal fibrosis effect, which is probably mediated by down-regulated TGF-β RI, TGF-β RII, and α-SMA in vitro.
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Journal: Fitoterapia - Volume 92, January 2014, Pages 72–78