Mono- and bis-furanone derivatives from the endolichenic fungus Peziza sp.

Seven new mono- and bis-furanones, pezizolides A–G (1–7), have been isolated from the crude extract of the endolichenic fungus Peziza sp. inhabiting the lichen Xanthoparmelia sp. The structures of the new compounds were elucidated mainly by NMR and MS methods. The absolute configuration of 1–4 was assigned by the application of CD exciton chirality method, and 1 was further supported by electronic circular dichroism (ECD) calculations, whereas that of 5 was deduced by Snatzke's method following the relative configuration analysis of its acetonide. The cytotoxity and antimicrobial activity of compounds 1–7 were tested.

The experimental CD spectrum of 1 in MeOH and the calculated ECD spectra of 8a–8b. Structures 8a and 8b represent two possible stereoisomers of 8.Figure optionsDownload high-quality image (63 K)Download as PowerPoint slide