کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538623 | 1559654 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort](/preview/png/2538623.png)
چکیده انگلیسی
Four new ligustilides chuanxiongnolide R1 (1), chuanxiongnolide R2 (2), chuanxiongdiolide R1 (3) and chuanxiongdiolide R2 (4) together with eight known derivatives (5–12) were isolated from the root of Ligusticum chuanxiong Hort. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, 1H–1H COSY, NOESY) methods. The absolute configurations were confirmed via the circular dichroism (CD) spectrum. The anti-inflammatory assay in LPS-triggered RAW 264.7 macrophages was carried out on the twelve compounds. 1, 3, 5 and 6 showed significant inhibitory effects against LPS-induced NO production.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 91, December 2013, Pages 21–27
Journal: Fitoterapia - Volume 91, December 2013, Pages 21–27
نویسندگان
Jian Huang, Xiao-Qing Lu, Cui Zhang, Jin Lu, Guo-Yu Li, Rui-Chao Lin, Jin-Hui Wang,