Labdane diterpenes from Chloranthus serratus

Five new labdane diterpenes (1–5), serralabdanes A–E, were isolated from the whole plant of Chloranthus serratus. Their structures were elucidated by spectroscopic methods, and the absolute configuration of the 12,13-diol moiety in serralabdane C (3) was determined by observing the induced circular dichroism (ICD) after addition of dimolybdenum teracetate in DMSO solution. Serralabdanes A–E (1–5) showed inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

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