Norbisabolane and eremophilane sesquiterpenoids from cultures of the Basidiomycete Polyporus ellisii

Three new 11,12,15-norbisabolane sesquiterpenoids, polisins A–C (1–3), and four new eremophilane sesquiterpenoids, polylisins A–D (4–7), were isolated from cultures of the Basidiomycete Polyporus ellisii. These new structures were elucidated based on extensive spectroscopic studies and the structures of polisin A (1) and polylisin A (4) were confirmed by single-crystal X-ray crystallographic analysis. All compounds were evaluated for their inhibitory activities against two isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2).

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