کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538682 | 1122147 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenolics from Leontopodium leontopodioides inhibiting nitric oxide production
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
Two new compounds, a neolignan (1), and a benzofuran derivative (2), along with 6 known compounds (3–8), were isolated from the aerial parts of Leontopodium leontopodioides. The structures of the new compounds were elucidated as (7R,8S)-3,5′-dimethoxy-4′,7-epoxy-8,3′-neolignane-5,9,9′-triol (1) and (2R)-12-hydoxy-4-methoxy-tremeton (2) on the basis of their spectroscopic data, respectively. All of the isolates were evaluated for their effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages and compounds 1 and 8 exhibited inhibitory activity with IC50 values of 35.80 and 24.41 μM, respectively.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 83, Issue 5, July 2012, Pages 883–887
Journal: Fitoterapia - Volume 83, Issue 5, July 2012, Pages 883–887
نویسندگان
Xin Li, Jian-Guang Luo, Xiao-Bing Wang, Jun Luo, Jun-Song Wang, Ling-Yi Kong,