Four new sesquiterpenes from Commiphora myrrha and their neuroprotective effects

Four new sesquiterpenes, myrrhterpenoids K−N (1− 4) have been isolated from the resin of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). Compounds 1 and 4 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.

Four new sesquiterpenes (1−4) have been isolated from Commiphora myrrha. Their structures were elucidated by spectroscopic methods. Compounds 1 and 4 showed neuroprotective effects.Figure optionsDownload high-quality image (87 K)Download as PowerPoint slide