Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production

As a part of our ongoing search for plant-derived compounds that inhibit nitric oxide production, the methanol extract of the roots of Vladimiria souliei was found to show significant inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded two most active sesquiterpenes, including a new compound, named souliene A (1) and alismol (2). Their structures were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). Two isolates showed promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells.

Graphical AbstractTwo bioactive sesquiterpenes were isolated from Vladimiria souliei. Their structures were elucidated by spectroscopic methods. Two isolates showed promising inhibitory effects on INF-γ-induced nitric oxide production.Figure optionsDownload as PowerPoint slide