کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538910 | 1122159 | 2011 | 6 صفحه PDF | دانلود رایگان |
A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.
Graphical AbstractFigure optionsDownload as PowerPoint slideViteagnusin I and 23 other phytoconstituents from the fruits of Vitex agnus‐castus were characterized; apigenin, 3‐methylkaempferol, luteolin, and casticin are weak, dose‐dependent ligands of delta and mu opioid receptors.
Journal: Fitoterapia - Volume 82, Issue 4, June 2011, Pages 528–533