کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538914 | 1122159 | 2011 | 13 صفحه PDF | دانلود رایگان |
Polyphenolics extracted from yaupon holly (Ilex vomitoria, Aquifoliaceae) (YH) leaves were investigated in human colon cells for their chemopreventive and anti-inflammatory activities. An activity-guided fractionation allowed the selection of YH flavonol-rich fraction due to its preferential inhibition of HT-29 colon cancer viability over the normal CCD-18Co colon cells. Quercetin and kaempferol 3-rutinosides, main components identified in this fraction, protected CCD-18Co cells against reactive oxidative species (ROS) in part due to increased activity of antioxidant enzymes. In addition, up-regulation of microRNA-146a (miR-146a) known as a negative regulator of pro-inflammatory NF-κB activation was the underlying molecular mechanism that protected CCD-18Co from inflammation.
Graphical AbstractYaupon holly protect colonic CCD-18Co cells from inflammation by inducing antioxidant enzymes, and microRNA-146a, which negative regulates TLR4-NF-κB activation and the downstream pro-inflammatory genes. Inhibition (), induction ().Figure optionsDownload as PowerPoint slideFigure optionsDownload as PowerPoint slideFigure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 4, June 2011, Pages 557–569