کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538916 | 1122159 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats](/preview/png/2538916.png)
This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain.
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Journal: Fitoterapia - Volume 82, Issue 4, June 2011, Pages 576–584